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INGREZZA® (valbenazine) capsules for adults with tardive dyskinesia (TD) Home Logo

FOR ADULTS WITH TARDIVE DYSKINESIA (TD)

REMISSION with INGREZZA

Rapid reductions in TD severity as early as 2 weeks.1-3,* 59% of patients achieved remission at 48 weeks.2,4,†

*Post hoc analysis from KINECT 3. Primary endpoint was change in AIMS total score (80 mg -3.2 [n=70] vs -0.1 [n=69] for placebo) from baseline to Week 6.

†Post hoc analysis from open-label KINECT 4. Remission defined as ≤1 on each AIMS item 1-7 at Week 48. Results are descriptive.

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FOR ADULTS WITH TARDIVE DYSKINESIA (TD)

HIGHLY EFFECTIVE1,*

More than reductions in TD severity—achieve remission with INGREZZA1,4,5,†

SEE REMISSION DATA

UNIQUELY SELECTIVE1,6,7,‡

Only INGREZZA: 100% on-target activity at VMAT27-9,‡

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THERAPEUTIC DOSE FROM DAY 11

Patients can start and stay on an effective dosage1

EXPLORE DOSING

PROVEN ACROSS THE WIDEST RANGE OF PATIENTS1,10

EXPLORE DOSING

FOR ADULTS WITH HUNTINGTON’S DISEASE (HD) CHOREA

control with INGREZZA

Rapid and sustained chorea reductions observed with INGREZZA as early as 2 weeks and through 2 years1,2,11,§

Change in TMC score from baseline through 104 weeks in interim analysis of long-term, open-label study.

VIEW HD CHOREA EFFICACY
Number 1 most prescribed VMAT2 inhibitor. 7 years and counting

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‡

Based on in vitro VMAT2 binding affinity of dihydrotetrabenazine (HTBZ) metabolites and the primary active metabolite of INGREZZA, + α HTBZ. The clinical significance of in vitro data is unknown and is not meant to imply clinical outcomes.

§

Change in TMC score from baseline through 104 weeks in interim analysis of long-term, open-label study.

REFERENCES:

  1. INGREZZA [package insert]. San Diego, CA: Neurocrine Biosciences, Inc.
  2. Data on file. Neurocrine Biosciences, Inc.
  3. Hauser RA, Factor SA, Marder SR, et al. KINECT 3: a phase 3 randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia. Am J Psychiatry. 2017;174(5):476-484.
  4. Correll CU, Citrome L, Singer C, et al. Sustained treatment response and global improvements with long-term valbenazine in patients with tardive dyskinesia. J Clin Psychopharmacol. 2024;44(4):353-361.
  5. Correll CU, Cutler AJ, Kane JM, McEvoy JP, Liang GS, O’Brien CF. Characterizing treatment effects of valbenazine for tardive dyskinesia: additional results from the KINECT 3 Study. J Clin Psychiatry. 2018;80(1):18m12278.
  6. Harriott ND, Williams JP, Smith EB, Bozigian HP, Grigoriadis DE. VMAT2 inhibitors and the path to INGREZZA (valbenazine). Prog Med Chem. 2018;57(1):87-111.
  7. Grigoriadis DE, Smith E, Hoare SRJ, Madan A, Bozigian H. Pharmacologic characterization of valbenazine (NBI-98854) and its metabolites. J Pharmacol Exp Ther. 2017;361(3):454-461.
  8. Brar S, Vijan A, Scott FL, et al. Pharmacokinetic and pharmacologic characterization of the dihydrotetrabenazine isomers of deutetrabenazine and valbenazine. Clin Pharmacol Drug Dev. 2023;12(4):447-456.
  9. Skor H, Smith EB, Loewen G, O’Brien CF, Grigoriadis DE, Bozigian H. Differences in dihydrotetrabenazine isomer concentrations following administration of tetrabenazine and valbenazine. Drugs R D. 2017;17(3):449-459.
  10. Deutetrabenazine [package insert]. Parsippany, NJ: Teva Neuroscience, Inc.
  11. Stimming EF, Claassen DO, Kayson E, et al. Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington’s disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2023;22(6):494-504.
  12. Data on file as of Q3 2024. Neurocrine Biosciences, Inc.
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Important Safety Information

Depression and Suicidality in Patients with Huntington’s Disease: VMAT2 inhibitors, including INGREZZA, can increase the risk of depression and suicidal thoughts and

Important Information

INDICATION & USAGE

INGREZZA® (valbenazine) capsules and INGREZZA® SPRINKLE (valbenazine) capsules are indicated in adults for the treatment of tardive dyskinesia and for the treatment of chorea associated with Huntington’s disease.

IMPORTANT SAFETY INFORMATION

Depression and Suicidality in Patients with Huntington’s Disease: VMAT2 inhibitors, including INGREZZA and INGREZZA SPRINKLE, can increase the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington’s disease. Balance the risks of depression and suicidality with the clinical need for treatment of chorea. Closely monitor patients for the emergence or worsening of depression, suicidal ideation, or unusual changes in behavior. Inform patients, their caregivers, and families of the risk of depression and suicidal ideation and behavior and instruct them to report behaviors of concern promptly to the treating physician. Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation, which are increased in frequency in patients with Huntington’s disease.