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INGREZZA® (valbenazine) capsules

Patient-reported outcomes in tardive dyskinesia

KINECT-PRO Patient Reported Outcomes

KINECT-PRO™: A Landmark, Phase 4, Open-Label Study1

  • KINECT-PRO is the first study to evaluate TD impact and burden using multiple validated patient-reported outcome measures; data shown here are for one of these measures (Tardive Dyskinesia Impact Scale™, or TDIS™)
  • This study was a phase 4, open-label, single-arm, interventional, prospective study of patients without use of a VMAT2 inhibitor within the last month.
  • Included 59 patients with schizophrenia, schizoaffective disorder, or mood disorder and at least mild TD*
  • Patients were started on INGREZZA® (valbenazine) capsules 40 mg for 4 weeks and could be adjusted based on patient needs (40, 60, or 80 mg) afterward for a total of 24 weeks of treatment

*Measured by AIMS Item 8 (global severity) score ≥2.


The Tardive Dyskinesia Impact Scale (TDIS) is the only PRO measure specifically designed for and validated in TD patients2

The TDIS is an 11-item questionnaire to evaluate how TD affects a patient’s daily functioning over the past 7 days. Each question is scored on a 5-point scale from 0 (no impact) to 4 (most impact), resulting in a score of 0 to 44.


Physical and social/emotional items
Physical and social/emotional items

Example question
Example question

LEARN MORE ABOUT THE VALIDATION OF THE TARDIVE DYSKINESIA IMPACT SCALE (TDIS)

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The VMAT2 inhibitor with clinically meaningful improvements in patient-reported TD impact1

AS MEASURED BY THE TARDIVE DYSKINESIA IMPACT SCALE (TDIS)

Mean change in TDIS from baseline to Week 241

Mean change in Tardive Dyskinesia Impact Score (TDIS)
Mean change in Tardive Dyskinesia Impact Score (TDIS)

SIMPLE FROM THE START

Only INGREZZA offers a therapeutic dose from Day 13

EXPLORE DOSING

SEE REAL-WORLD RESULTS
WITH INGREZZA

View videos of real-world patients with TD treated with INGREZZA

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INGREZZA CLINICAL
SAFETY DATA

INGREZZA was studied across a broad range of TD patients

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REFERENCES:

  1. Data on file. Neurocrine Biosciences, Inc.
  2. Farber RH, Stull DE, Witherspoon B, et al. The Tardive Dyskinesia Impact Scale (TDIS), a novel patient-reported outcome measure in tardive dyskinesia: development and psychometric validation. J Patient Rep Outcomes. 2024;8(1):2.
  3. INGREZZA [package insert]. San Diego, CA: Neurocrine Biosciences, Inc.
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Important Safety Information

Depression and Suicidality in Patients with Huntington’s Disease: VMAT2 inhibitors, including INGREZZA, can increase the risk of depression and suicidal thoughts and

Important Information

INDICATION & USAGE

INGREZZA® (valbenazine) capsules and INGREZZA® SPRINKLE (valbenazine) capsules are indicated in adults for the treatment of tardive dyskinesia and for the treatment of chorea associated with Huntington’s disease.

IMPORTANT SAFETY INFORMATION

Depression and Suicidality in Patients with Huntington’s Disease: VMAT2 inhibitors, including INGREZZA and INGREZZA SPRINKLE, can increase the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington’s disease. Balance the risks of depression and suicidality with the clinical need for treatment of chorea. Closely monitor patients for the emergence or worsening of depression, suicidal ideation, or unusual changes in behavior. Inform patients, their caregivers, and families of the risk of depression and suicidal ideation and behavior and instruct them to report behaviors of concern promptly to the treating physician. Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation, which are increased in frequency in patients with Huntington’s disease.